Flucloxacillin Side Effects

Updated April 17, 2017

Flucloxacillin (brand name Floxapen) is an antibiotic in the penicillin group used to treat bacterial infections. It is considered effective and safe to take, but like most medications it does have the possibility of side effects.

Gastrointestinal Distress

Some people taking Flucloxacillin may experience nausea, vomiting or diarrhoea.

Other Infections

While using Flucloxacillin, you may experience an overgrowth of organisms that are not susceptible to this antibiotic. This could lead to infections such as thrush.


Flucloxacillin may cause the large intestine to become inflamed.


Allergic reactions to Flucloxacillin may cause rashes, hives or itching.

Jaundice and Hepatitis

Flucloxacillin could cause jaundice, which is a yellowing of the skin, or inflammation of the liver, such as hepatitis.


If you are allergic to penicillin or cephalosporin type antibiotics, do not use Flucloxacillin. Do not use this medicine if you have a history of liver problems or jaundice caused by previous treatment with Flucloxacillin.


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About the Author

Anna Sanclement has been writing fiction and nonfiction for about 10 years. In addition to writing online articles and content, Sanclement has written a novel and contributes a monthly sci-fi and astronomy column at "Around Wellington Magazine." She holds a bachelor's degree in liberal arts from Florida Atlantic University.