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What is the difference between phentermine & phentramine?

Phentermine is a prescription drug used for weight loss. Phentramine is an over-the-counter supplement marketed as an "all-natural" alternative to Phentermine.

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Phentermine HCl (Adipex-P)

Phentermine hydrochloride USP is manufactured by GATE Pharmaceuticals. It is sold under the brand name Adipex-P. Physicians prescribe it to assist weight loss in obese patients (BMI >30) who are struggling with diet and exercise. It works by suppressing appetite. A relative of the amphetamines, phentermine is a stimulant drug that increases metabolism and raises blood pressure. It should not be used for more than a few weeks.


Phentramine and Phentramine HCl are appetite suppressant supplements sold by PGHP. They are heavily marketed and widely available for order over the Internet. Phentramine consists of 20:1 Hoodia extract, Guarana extract, and a proprietary blend of Cha de Bugre, Ginseng, Citrus aurantium and black pepper. Hoodia is a succulent that is used for appetite suppressant by the native peoples of the Kalahari Desert. The other herbs in the formula are mild stimulants.

Phentramine HCl

Phentramine HCl is a very different formula, consisting of phenylethylamine HCl (similar to the chemical formula of Phentermine), and a series of other stimulant chemicals, including 100 mg of caffeine.


Avoid stimulant drugs such as Phentermine HCl and Phentramine HCl if you have a history of high blood pressure, hyperthyroidism, glaucoma, diabetes, drug abuse or addiction, or if you have recently taken monoamine oxidase inhibitors.

Never take two or more stimulant drugs together.

Do They Work?

There is little evidence that either Phentermine or Phentramine is effective for long-term weight loss. Appetite suppressant drugs lose their effects after a few weeks, as the body becomes tolerant of them.

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About the Author

Stephanie Draus, ND

Stephanie Draus is a naturopathic doctor and assistant professor of clinical sciences at National University of Health Sciences. She has practiced in Chicago as a health consultant since 2005. She is a graduate of the National College of Natural Medicine in Portland, Oregon.

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