Side Effects of Tri-Creatine Malate

Updated November 21, 2016

Tri-creatine malate is a white powder that is created from creatine monohydrate and malic acid and is most commonly used as a supplement for those wishing to increase muscle mass. Tri-creatine malate encourages the production of adenosine triphosphate, which is responsible for muscle growth and contraction. Tri-creatine malate may increase lean body mass, muscular ability, and overall physical recovery. Some users have reported side effects when using the supplement.

Water Retention

One of the most common side effects of tri-creatine malate (or any form of creatine) is water retention. This may result in feelings of bloating, nausea and stomach discomfort. Increasing fluid intake may reduce bloating and stomach pain.


Because tri-creatine malate draws water from the rest of the body to the muscles, some individuals may become dehydrated when taking the supplement. Increase overall fluid intake when consuming tri-creatine malate.

Decrease in Energy

Individuals who take tri-creatine malate and then discontinue its use may note a change in their energy levels. This should return to normal as the body adjusts to baseline function.

Unusual Side Effects

Some less common side effects of tri-creatine malate can include irregular heartbeat, changes in skin pigment, and harm to the liver, kidneys, or heart. Always consult a physician before taking any nutritional supplement. Pregnant or lactating women should not take creatine in any form because not enough is known about the safety of creatine during pregnancy or lactation. Children under the age of 18 should also avoid consuming creatine in any form. It is important to note that the U.S. Food and Drug Administration (FDA) does not monitor nutritional supplement effectiveness or safety.

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About the Author

Meredith Jameson writes early childhood parenting and family health articles for various online publications. She holds a Bachelor of Arts in history from San Francisco State University.