Guitar Hero and Rock Band both feature wireless guitars on the Wii. They are not stand alone controllers and must be synced with the Wii remote, which in turn, must be synced to the Wii. The Wii remote can be stored in the small compartment on the back of the guitar while playing the game. When connecting multiple guitars/controllers, the sync process must be repeated each time.
Turn on the Wii. Open the side panel and press the "Sync" button.
Remove the cover off the back of your Wii remote. Press the "Sync" button.
Insert the neck of the guitar onto the guitar.
Open the back panel on the guitar.
Attach the connector from the guitar to the Wii remote. Place the Wii remote into the guitar as described on the illustration on the guitar.
Re-attach the cover to the Wii remote. Close the back panel on the guitar.