Microsoft OneNote can be a useful program for business or personal computing, but it is also a memory-heavy program that can slow your computer down unnecessarily if you do not use it. If you want to keep the program loaded on your computer but want to disable it from loading, you can remove OneNote from your computer's start-up sequence so it will simply be stored, unopened, until you manually tell the computer to open it again. The method for doing this varies depending on your operating system.
Click the "Start" orb in the bottom-left corner of your screen, then select "All Programs."
Click "Windows Defender > Tools > Software Explorer," then click "Startup Programs" in the box labelled "Category."
Search the list for Microsoft OneNote, then click "Disable."
Click "Yes," then click "OK" to save your change and exit. Restart your computer if you are prompted to do so.
Click "Start" in the lower-left corner of your screen (also called the "Start orb") and click "Control Panel."
Click "System and Security > Administrative Tools."
Double-click "System Configuration" once the Administrative Tool window loads. You may be asked for an administrative password if there is one set on your computer. Type this in the field provided if prompted and press "Enter."
Click the "Startup" tab, then click to remove the check mark from the box next to "Microsoft Office OneNote." Click "OK," then follow the prompts to restart your computer.
Click on "Start" in the lower-left corner of your screen, then click "Programs > Startup."
Right-click on the Microsoft Office OneNote icon.
Click "Delete." This will delete the shortcut in the "Startup" folder, keeping your computer from running the program at start-up. This will not delete the program; it can still be accessed from the "Programs" menu under the Microsoft Office folder if you want it in the future.
Restart your computer if prompted to do so.
Uninstall the program by selecting "Add or Remove Programs" or "Programs and Features" in the "Control panel" window and follow the on-screen instructions.