Cleaning a crystal perfume bottle is not particularly difficult, but you will need some slightly surprising supplies. Also, you will have to have a light touch so that you do not nick or scratch your bottle while you are cleaning. In the end, however, you will be surprised at how similar cleaning your fine crystal perfume bottles is to cleaning any other type of fine crystal or jewelry.
Remove all your hand and wrist jewelry. Some types of stones in rings or bracelets can scratch your crystal. Since you will be holding it and rotating it during the cleaning, you should remove them just to be safe.
Prepare your cleaning bowl. Fill the shallow bowl with warm water and a teaspoon or so of the mild soap. Place the bowl in the sink if possible. Lay one of the hand towels in the bowl so that if you accidentally drop your crystal perfume bottle, it will be less likely to shatter.
Remove any metal parts of the bottle. Most perfume bottles will have a metal top and you should take this off before cleaning the crystal so that it does not rust. If you need to clean this part of the bottle, then just use a damp rag and then dry it thoroughly.
Rinse the outside of the bottle in the soapy water. You can use the test tube brush to gently work off any grime or dirt that has gotten into the smaller details of the crystal. Do not scrub hard, but use gentle, circular motions.
Work the test tube scrubber gently into the neck of the bottle. Be very careful here so that you do not chip the neck. The bristles will do the cleaning work for you so you do not need to scrub. Once the test tube scrubber is in the bottle, you can gently twist it to clean the inside, which should not be nearly as dirty as the outside because it is smooth and cannot be handled. If you do have a lot of grime to remove, just be patient. Rinse out the inside periodically and then gently return to scrubbing and it will eventually all come out.
Rinse the entire crystal perfume bottle. Use warm water and fill and empty the bottle several times. Also rinse the outside thoroughly. Any soap scum will leave your crystal looking unwashed and grimier than it started.
Let the perfume bottle air dry completely. Lay it on a clean hand towel and do not disturb it for 24 hours. Once it is dry, you can reassemble it if you like.
If you have stubborn grime inside the bottle, fill it with a weak water and bleach solution (just a few drops of bleach) and let it sit for a few hours before cleaning. When you pour out the bleach mixture, a lot of the stubborn grime should come with it.