Ziana for Wrinkles

Written by kimberli nalven
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Ziana for Wrinkles
As skin ages and loses elasticity, new wrinkles form predominently around the eyes, mouth and across the forehead. (hand for heart image by amlet from Fotolia.com)

While Ziana gel is specifically marketed as a topical gel treatment for acne, according to Leslie Baumann, MD, at YahooHealth.com, one of the key active ingredients in the product also gives it significant anti-ageing properties. Baumann notes that Ziana contains Tretinoin, a prescription-strength retinoid, and retinoids are currently one of the most popular weapons dermatologists have for slowing the skin's ageing process and improving existing signs of ageing like fine lines and wrinkles.


Under its generic name, Ziana is listed as clindamycin phosphate and tretinoin. It is a gel product that combines two active ingredients: an antibiotic and a retinoid. The retinoid component of the product, Tretinoin, generates hyaluronic acid and collagen production in the skin, giving the skin a firmer, fuller appearance. It's also an exfoliator that improves a skin's texture and tone while simultaneously encouraging cell turnover to reduce brown spots and discolourations.

Ziana for Wrinkles
The retinoid Tretinoin in Ziana can reduce existing signs of ageing like fine lines and wrinkles around the eyes. (regard image by Nath Photos from Fotolia.com)


According to Dr. Baumann, dermatologists are starting to prescribe Ziana for a variety of skin issues. Although reviews at DailyBeauty are from new users of the product, making results inconclusive, some users indicate that their dermatologists are now prescribing Ziana for more than acne treatment. In addition to its acne-fighting benefits, it exfoliates and plumps the skin, reduces hyperpigmentation and encourages a more radiant, healthy glow on the skin.

Ziana for Wrinkles
Retinoids can help reduce discolouration and unwanted pigmentation of the skin. (freckles. image by Anna Chelnokova from Fotolia.com)

Side Effects/Interaction

Erythromycin-containing products can interact with Ziana and reduce the effectiveness of both products since they are both antimicrobials, according to drugs.com. Using Ziana while taking neuromuscular blocking agents can amplify the effects of both drugs, so they shouldn't be used together. Ziana can make skin more sensitive to soaps, cleansers or cosmetics that are harsh, abrasive or medicated. Contact your physician if your skin becomes crusty, blistered, red or swollen after taking Ziana, or you develop watery or bloody diarrhoea.

Ziana for Wrinkles
When using Ziana, choose cosmetics and cleansers that are gentle to avoid irritating sensitive skin. (Cosmetics image by Ellanorah from Fotolia.com)


The manufacturers of Ziana caution consumers with Crohn's disease, ulcerative colitis, or any history of bowel or digestive issues to discuss those conditions with their physician before beginning a regimen of Ziana. In addition, since Ziana contains an antibiotic, anyone who has developed colitis with past antibiotic use is not a good candidate for Ziana. Pregnant women, nursing mothers and children under 12 are not encouraged to use Ziana as either an acne or anti-ageing treatment.

Ziana for Wrinkles
Since the medication may affect a foetus and can be found in breast milk, pregnant or nursing mothers should not take Ziana. (Pregnant 1 image by Infs from Fotolia.com)

Expert Insight

Retinoids, indicates Dr. Braumann, are typically prescribed for patients with acne problems because they exfoliate the dead facial skin cells that can cause blocked pores and lead to acne. However, dermatologists have discovered that acne patients treated with retinoids for acne lesions had fewer dark spots and wrinkles than patients not treated with retinoids. Due to this development, more and more dermatologists are now prescribing acne treatments with retinoids for anti-ageing purposes.

Ziana for Wrinkles
Only the acne treatments featuring retinoids are being used as anti-ageing treatments. (senior doctor 10 image by Paul Moore from Fotolia.com)

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