The effects of long-term omeprazole

Updated February 21, 2017

Omeprazole is a prescription medication used to treat heartburn and gastro-oseophageal reflux disease. While there are no damaging effects to the body from using Omeprazole over long term periods, side effects can be long term, lasting for hours, weeks, or for as long as you continue to use the drug. If you are experiencing negative long-term side effects as a result of taking Omeprazole, you should inform your physician, since he will need to adjust your dosage.


Take Omeprazole exactly as it was prescribed to you; do not alter your dosage. If you forget to take your dose, take your missed dose as soon as you remember. Never double up on Omeprazole, since it may result in overdose. Omeprazole overdose can be fatal. Symptoms include blurred vision, increased heartbeat, headache, blurred vision, feeling confused, drowsiness, nauseous, vomiting or sweating. Call the poison control centre (800-222-1222) if you are experiencing an Omeprazole overdose.

Side Effects

Side effects of Omeprazole can be short- or long-term, depending on your reaction to the drug. Patients who report long-term side effects of Omeprazole usually experience headache or diarrhoea. Be sure to talk with your doctor if you are experiencing any negative reactions, since he may need to adjust your dosage or possibly prescribe a different medication to treat your side effects.

Severe Side Effects

Some side effects of Omeprazole can be considered severe and may be long-lasting or fatal. If you are experiencing a severe side effect of Omeprazole, get emergency medical help right away. Severe side effects of Omeprazole include hives; trouble breathing; chest tightening; swelling of the mouth or lips, as well as tongue; chest pain; dark urine; flu-like symptoms of fever or chills; heart racing or pounding; blistered skin; swelling of the hands, ankles or feet; vision changes or a yellowing of your skin.

Medical Interactions

Certain conditions and medications can cause an interaction with Omeprazol, which may cause side effects to last for prolonged periods of time. Tell your doctor about all medications you are currently using, including over-the-counter medications. Do not take Omeprazol if you are taking Voriconazole without talking to your doctor first. Other drugs that cause further interaction with Omeprazol include Warfarin, Clopidogrel, Cilostazol, Diazepam and Digoxin.

Things to Avoid

Do not operate a motor vehicle or perform complex tasks before you understand how this drug can affect you. Omeprazole can cause drowsiness. Do not use Omeprazole if you are taking an HIV Protease Inhibitor. Do not use Omeprazole if you are pregnant or planning to become pregnant. Do not use Omeprazole if you are breastfeeding unless you receive your doctor's approval.

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About the Author

James Clark began his career in 1985. He has written about electronics, appliance repair and outdoor topics for a variety of publications and websites. He has more than four years of experience in appliance and electrical repairs. Clark holds a bachelor's degree in political science.