We Value Your Privacy

We and our partners use technology such as cookies on our site to personalise content and ads, provide social media features, and analyse our traffic. Click below to consent to the use of this technology across the web. You can change your mind and change your consent choices at anytime by returning to this site.

Update Consent
Loading ...

What Is Wound Epithelialization?

Epithelialization is the natural act of healing dermal and epidermal tissue in which epithelium grows over a wound. Epithelium is a membranous tissue made up of one or more layers of cells that contains very little intercellular substance.

Loading ...


Epithelialization is a complex process of tissue repair consisting of three overlapping phases.

Inflamatory Phase

When the skin is wounded, blood comes into contact with collagen that triggers blood platelets to secrete inflammatory factors. Homeostasis (stopping blood loss) takes place through the clotting cascade. Plasma proteins are released to attract cells that phagocytise (ingest foreign particles). This cellular migration to the wound area is the first line of defense against debris, bacteria, and damaged tissue.

Profliferative Phase

Two to five days after the onset of the wound, patent cells begin to sprout cells (angioblasts) into the wound, forming new capillary loops. Type III collagen is produced forming "granulation tissue."

Remodeling Phase

Remodeling begins when special cells (myofibroblasts) appear. Their muscle-like contracting proteins act on the wound as a whole, shrinking the wound.


Wound-healing disorders interfere with natural epithelialization. Chronic wounds can be recognized by a loss of skin around the wound. Such wounds can result in serious medical complications and require immediate and intense medical intervention.

Loading ...

About the Author

Lisa Dorward was a corporate financial executive and business consultant for more than 15 years before becoming a writer in 2003. She has B.A. degrees in both history and creative writing and earned her M.F.A. in creative writing in 2008, specializing in novel-length historical fiction.

Loading ...