How to Treat Serious Side Effects of Omeprazole

Updated April 17, 2017

Omeprazole is a common medication used to treat gastric reflux, also called acid reflux, and other stomach problems. The medication is sold under many different names, the most familiar being Prilosec, and also is available as a generic. Mild side effects are the most common when taking omeprazole and most symptoms stop after a few days. But omepazole has serious side effects as well.

Omeprazole is used to treat stomach problems, including ulcers, acid-related illnesses like acid reflux and GERD (gastro-oseophageal reflux disease), erosive esophagitis and consistent heartburn.

Most mild symptoms will lessen or go away as your body adjusts to the medicine. Side effects of omeprazole include diarrhoea, nausea, upset stomach, gas and loss of appetite. Mild headache and dizziness are possible too.

Take omeprazole before meals to get the proper dose of medicine and avoid stomach upset. This type of medication works best on an empty stomach.

Use a prescribed or suggested amount of acetaminophen (like Tylenol) for headaches from omeprazole. Other non-prescription pain medication, such as ibuprofen and aspirin, can cause more stomach upset.

Take calcium if you are concerned about osteoporosis or other bone-density issues. A 2006 study in the Journal of American Medicine reports that hip fractures can increase with omeprazole type medications and adding calcium to the diet is prudent.

Report severe side effects of omeprazole to your doctor. If you experience respiratory problems, swelling of the face, lips or tongue, severe nervous system issues, hip fractures, nervousness, joint pain, chest pain, ringing of the ears, swelling in the stomach area, coughing, vision change, excessive thirst or sleep disturbances, contact your doctor as soon as possible.


Stop taking omeprazole if you develop any severe side effects and call your doctor immediately.

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About the Author

Beth Richards, a freelance writer since 2002, writes about health and draws from her 25 years as a licensed dispensing optician. She has authored several books, writes for national magazines including "Country Living" and "Organic Family" and is a health and wellness features writer for several publications. She is earning a Bachelor of Arts in English from the University of Maryland.