Estriol Cream Side Effects

Updated April 17, 2017

Estriol cream is a non-prescription treatment for the hot flashes and vaginal dryness associated with menopause. It has been proven safe with few, if any, side effects.


One of the primary hormones of pregnancy, estriol is a form of oestrogen produced by the ovaries.


Aside from relieving the symptoms of menopause, estriol has proven safer than other forms of oestrogen, like estrone and estradiol, in hormone replacement therapy. Unlike its counterparts, estriol doesn't increase the risk of breast or uterine cancers, nor does it cause blood clots. It's also been shown to prevent skin ageing.


One gram of estriol cream is applied to the vagina each night for one week. After that, the frequency is reduced to two or three times each week as needed.


The most common side effect reported with estriol use is mild vaginal burning upon application. This sensation typically goes away after the first day or two of treatment.


Estriol cream is not intended to be used as a sexual lubricant.

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About the Author

William Lynch has been a freelance writer for the past fifteen years, working for various web sites and publications. He is currently enrolled in a Master of Arts program in writing popular fiction at Seton Hill University. He hopes to one day become a mystery novelist.