Methoxyisoflavone is a flavonoid, typically taken as a dietary supplement and marketed to athletes interested in increasing strength and muscle mass, particularly during training, according to the National Center for Biotechnology Information. Experts at Health Library clarify that methoxyisoflavone is touted as a dietary supplement that works like an anabolic steroid but without the testosterone-like side effects. However, there are no studies to prove its efficacy or the absence of the indicated side effects.
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Steroid-like Side Effects
Users of methoxyisoflavone, a supplement that claims to provide hormone-like benefits similar to anabolic steroids without their testosterone- or oestrogen-like side effects, shouldn't experience an increase in acne, a decrease in good cholesterol levels (HDL), an enlarged prostate or male pattern baldness, according to eVitamins. However eVitamins cautions that no conclusive studies support the long-term absence of these side effects.
Possible interactions with drugs or dietary supplements that may occur with methoxyisoflavone are unknown, according to eVitamins. Health Library indicates that the limited studies published on the uses, effects and interactions of methoxyisolfavone have no reasonable credibility because they weren't published in peer-reviewed journals under strict regulations.
Although methoxyisoflavone is not found in substantial amounts in any one food, according to Health Library, it is an isoflavone found in soy products. The substance is considered an active part of soy products and contains oestrogen-like properties. The FDA allows foods containing soy products to be labelled as heart-healthy because of their cholesterol-lowering properties.
The National Center for Biotechnology Information reports that in a December 2003 published study on the effects of methoxyisoflavone, even the projected muscle-building effects of the supplement were not realised. The study concludes that the anabolic/catabolic hormone levels of the weightlifting athletes who used the supplement were unaffected. The only viable results reported are in the prevention of bone loss such as what occurs in osteoporosis and the reduction of bone resorption.
Dietary supplements such as methoxyisoflavone are not as strictly monitored or regulated by the U.S. Food and Drug Administration as drugs and food products are. So there are no federal requirements stipulating that a dietary supplement must live up to its efficacy claims or be tested as safe. Safety and efficacy are the responsibility of the manufacturer, so consumers should consult their physicians or pharmacists before starting a new dietary supplement.
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- National Center for Biotechnology Information: Effects of Methoxyisoflavone, Ecdysterone and Sulfo-Polysaccharide Supplementation on Training Adaptations in Resistance-Trained Males
- eVitamins: Methoxyisoflavone Side Effects
- Health Library: Methoxyisoflavone
- U.S. Food and Drug Administration: Dietary Supplements