What Is Clindoxyl Gel?

Updated April 17, 2017

Clindoxyl gel is a combination of 1 per cent clindamycin phosphate and 5 per cent benzoyl peroxide. Clindamycin phosphate and benzoyl peroxide are the top topical acne treatment medications, and Clindoxyl gel combines them to increase the treatment efficacy. It treats moderate forms of acne vulgaris (inflammatory acne) that present with comedones and papulopustules. Clindoxyl falls under the medication category of antibiotics. Since acne vulgaris is bacteria trapped under the skin, this antibiotic gel is very successful at treating acne vulgaris. It is a prescription medication available only through a doctor.

Side Effects

The most common side effects of Clindoxyl gel are pruritus, dryness and erythma of the skin. Rarely, worsening of acne is possible as well as paresthesia. Even the common Clindoxyl side effects do not usually occur when the patient uses the product as prescribed.


Use the product on clean, dry skin to minimise the chances of side effects occurring. The first few days of using Clindoxyl gel, wash the product off the face a few minutes after applying it to reduce irritation. If skin becomes irritated, reduce the frequency of application to every other day. For those with sensitive skin, minimise side effects by applying less of the product. If also using a retinoid treatment, patients should apply the retinoid and Clindoxyl at opposite times of the day to receive the full benefits of each.


There are some types of acne that Clindoxyl does not work well on. These include cystic acne and acne that is purely comedones. These patients require a different treatment for successful elimination of acne.


Clindoxyl gel is more effective than clindamycin phosphate or benzoyl peroxide when used alone. Because of the low risk of side effects, for many patients Clindoxyl gel is a better treatment choice than oral medication. Clindoxyl gel is a cost-effective treatment, and most insurance plans cover this medication.


Most doctors recommend once-daily application of Clindoxyl gel to the affected area. Apply a layer of Clindoxyl over the whole area of acne-prone skin. Clindoxyl gel is not just for spot treatment of blemishes.


People who previously had a reaction to any product containing clindamycin, benzoyl peroxide, lincomycin or any other ingredient included in Clindoxyl should not use this medication because of the risk of severe side effects. Other health problems that contraindicate the use of Clindoxyl gel are regional enteritis, antibiotic associated colitis and ulcerative colitis.

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About the Author

Katie Duzan is an accomplished writer who lives in Cary, N.C. She has been a writer since 2006. She has published a variety of articles on websites such as Duzan holds a Bachelor of Science in business administration and computer information systems from the University of Arkansas, and currently attends the University of North Carolina at Charlotte where she is pursuing her Master of Arts in special education.