Side Effects of Drysol

Updated November 21, 2016

Drysol is an aluminium chloride solution used to treat hyperhidrosis, or excessive perspiration. It has recently become available as an over-the-counter medication. Formerly, it was available only by prescription. It contains the same chemical used in some antiperspirants, but in a higher concentration.


Drysol, like other antiperspirants, works by blocking the sweat glands. Because it is used topically, it is unlikely to have side effects that affect parts of the body it is not applied to. Although it is possible that Drysol could interact with other drugs, no interactions are known. Ask your doctor before using Drysol if you take medication, especially if you use a topical medication on the same parts of your body you want to use Drysol on.


The most common side effects associated with Drysol are irritation, a burning or prickling sensation, redness, swelling, or a rash in the area the product was applied to. These side effects are more common with Drysol than with typical antiperspirants because of the higher concentration of aluminium chloride. They are also more likely to occur when Drysol is used on the underarms than on other parts of the body.


Some people are more prone to developing a rash, irritation, or other side effects. The side effects are most common in people who have sensitive skin, eczema, or allergies to soaps or perfumes. Women who shave their underarms may find that side effects are more pronounced if they apply Drysol after shaving. If you have impaired kidney function, consult your doctor before using Drysol.


Although rare, serious allergic reactions to aluminium chloride (the active ingredient in Drysol) have occurred. Symptoms of an allergic reaction include widespread rash, difficulty breathing, swelling of the face, lips, or tongue, a sensation of tightness in the chest and itching over the entire body. If you experience these symptoms while using Drysol, stop using the product immediately and call your doctor.

Expert Insight

Drysol is used differently from most antiperspirants. It can also be used on many different parts of the body. Drysol should be applied only at night, and washed off in the morning to help prevent irritation and rashes. It may be helpful to cover the area Drysol is applied to by wearing gloves, socks, or a T-shirt. This can prevent the medication from being rubbed off while you sleep and will make it more effective.

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