Side Effects of Drontal Plus for Canines

dog image by Ergün Ã--zsoy from

Drontal Plus is a product used to treat infestations of roundworms, hookworms, tapeworms and whipworms in canines. Drontal Plus is composed of three different drugs: Praziquantel, Pyrantel pamoate and febantel. The medication is available only thorough a veterinarian's prescription and should not be used otherwise.

Drontal Plus is administered in tablet form and is available in three sizes: puppies and small dogs, medium sized dogs and large dogs. Though the drug is relatively safe, there are some side effects that dog owners should be familiar with before giving it to their pet.

Nausea and Vomiting

Nausea and vomiting may occur after giving your dog Drontal Plus. The drugs used to kill the worms can cause upset stomach and nausea, and some dogs may vomit from this. This is not uncommon, especially if your dog has a sensitive stomach.


Drontal Plus may cause diarrhoea in some dogs. The dog's gastrointestinal, or GI, tract may become upset, and the stress on the system can lead to diarrhoea. Also, the passing of dead worms can upset the GI and can cause diarrhoea as well.

Less Common Side Effects

If a large number of worms are present when Drontal Plus is administered, it may become difficult for the dog to pass all of the dead worms in its stool. In this instance, the dog's colon may become impacted, or blocked, by the sheer number of dead worms trying to be passed. This is not a common occurrence, but it does happen more often with very small or young dogs. Impaction is quite serious, so if you suspect it, seek veterinary care immediately.

Pregnant Female Side Effects

Drontal Plus contains both febantel and praziquantel, which should not be given to pregnant females. The combination of these two drugs has been shown to increase incidences of abortion and fetal abnormalities, especially when given to dogs during early stages of pregnancy.