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How long does doxycycline hyclate stay in your system?

Updated April 17, 2017

Doxycycline Hyclate is an antibiotic commonly called Doryx used to treat a number of bacterial diseases from pulmonary infections to Anthrax. Uninhibited by food consumption, it passes into the bloodstream through the digestive system and is filtered out of the body through the liver. While it does not have many side effects, it has caused some issues with certain patients.

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Doxycycline Hyclate (common brand name Doryx) is a man-made broad spectrum antibiotic that comes from oxytetracycline. It is prescribed in doses from 50 mg per capsule to 200 mg per capsule. Regular dosing instructions (one tablet twice a day) indicate it lasts in the body for about 12 hours.


Doxycycline Hyclate is used for a range of bacterial infections and may be used in place of penicillin, in cases where penicillin is inadvisable such as allergies. It can be used as a malaria prophylaxis (malaria preventive) for those travelling into countries where infection is a possibility, primarily for travellers who will be gone for four months or less. Also, it has been shown to be effective in slowing the progression of a certain strain of Anthrax.


Doxycycline is taken in capsule form and absorbed into the bloodstream through the digestive system allowing it to move through the body to combat bacterial infections. The liver cleans the drug out of the blood and concentrates it in urine and faeces to remove it from the body.


Doryx is not inhibited by food being consumed though a full glass of water is recommended to keep down throat and stomach irritation while taking the medication. Though the drug has an almost 100 per cent absorption into the body, it is dependent on absorption through digestion and filtering out through the liver, so problems with either system may cause problems with the medication. Only a doctor can ascertain if such problems are present and adjust the medication accordingly.


Doryx does not guarantee protection against malaria, but only helps to prevent the disease. Regular precautions should be taken to avoid being bitten by mosquitoes.

It crosses the placenta and affects the foetus, so it is not recommended for pregnant women.

The drug may cause hypersensitivity to sunlight and UV rays. Monitor time spent in the sun closely.

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About the Author

A. E. Hurt

Alledria Hurt is an entertainment writer from Savannah, Ga., and proud graduate of Armstrong Atlantic State University with a bachelor's in English and a master's in international studies. Now she shares her unique view with the world at large in her writing.

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