What Does a High Alkaline Phosphatase Level Indicate?

Updated November 22, 2016

Alkaline phosphatase (ALP) is an enzyme produced primarily in the liver. The kidneys, intestine and bones also contribute in smaller amounts. As a clinical diagnostic tool, elevated alkaline phosphate should be assessed along with other enzymes, but can indicate a number of medical conditions.

Liver Disease or Damage

An elevated alkaline phosphatase can be indicative of conditions such as gallstones, hepatitis, cirrhosis and liver cancer.

Bone Diseases

Bone diseases such as rickets, osteomalacia and Paget's disease cause elevated ALP levels, as do bone tumours or cancer. The enzyme level may also rise during the healing of a bone fracture, and in that instance would not be suggestive of malignancy.

Other Causes

Though not as common, if liver and bone disease are ruled out in the presence of an elevated ALP, other causes include heart attack or heart failure, kidney cancer, sepsis, hyperparathyroidism and mononucleosis.

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