GenTeal Eye Drops Vs. Systane Eye Drops

Written by sharon perkins
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GenTeal and Systane are two drops commonly used for dry eye. According to the University of Illinois Eye and Ear Infirmary, choice of eye drops should be based on two factors--preservatives and ingredients that protect the surface of the eye.

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Ten to 20 per cent of people are affected by dry eye. Over-the-counter eye drops like GenTeal and Systane are used to decrease the dry, gritty irritation of dry eye.


Systane consists of polythene glycol 400 0.4 per cent (lubricant), propylene glycol 0.3 per cent (lubricant), hydroxypropyl guar and polyquaternium-1 as a preservative. GenTeal is composed of 0.3 per cent hydroxypropylmethyl cellulose with GenAqua (sodium perborate) as a preservative


The preservatives used in both drugs are considered acceptable by the University of Illinois. Polyquaternium-1 and sodium perbonate are less damaging to the eye surface than more commonly used preservatives.


Hydrogels increase viscosity and keep tears on the eye longer. The hydrogel in GenTeal is hydroxypropylmethyl cellulose (HPMC). Systane uses two hydrogels, hydroxypropyl-guar, which creates a stronger tear film rather than replacing it, and propylene glycol.

Making a Choice

The choice of eye drop is an individual one. Both drops contain preservatives not considered harmful to the eye, and both contain hydrogels. Trying both drops to see which works best for you is a reasonable option.

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