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Xylene substitutes

Updated July 18, 2017

Xylene, also referred to as xylol, is any of three different isomeric liquid substances used as a solvent in the manufacture of dyes, resins, insecticides, fuels, perfumes and films. Xylene is highly toxic and can cause a host of dangerous side effects, including damaged neurological function, fatigue, mood swings, irritability and dizziness. Scientists have thus sought and developed a number of safer xylene substitutes, including the following list of leading industry alternatives.

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Pro-Par Clearant

Developed by Anatech Ltd., Pro-Par Clearant is an ideal alternative to xylene. The formula possesses the same evaporation rate, penetration rate and drying time as xylene, is recyclable and sustains a small degree of water tolerance.


An almost odourless formula with low toxicity levels, Clear-Advantage is another xylene substitute available from Polysciences, Inc. (see Resources). Clear-Advantage is distinctive in that it offers faster drying time than xylene.

Clear-Rite 3

Clear-Rite 3, produced by Richard-Allan, is similar to Pro-Par Clearant in that it has the same evaporation rate, penetration rate and drying time of xylene. Unlike Pro-Par, however, Clear-Rite has zero water tolerance.


Histosolve is a Shandon product and another xylene mimic with equal evaporation rate, penetration time and drying time. It is also recyclable, but like Clear-Rite it has zero water tolerance.

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About the Author

L.W. Westerfield is a writer, editor and blogger. Her interests include food, culture, holistic health, yoga and literature. She has written for "USA Today Magazine" and a variety of southern California newspapers. Westerfield is a certified Hatha yoga instructor and a Whole Foods Nutrition Counselor with a focus in macrobiotics and traditional Eastern healing arts.

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