How to Calculate the A/G Ratio

The albumin/globulin ratio measures the relative amounts of albumin and globulin a patient has. Albumin and globulin are classes of proteins. Albumin prevents fluid from leaking out of the blood vessels. Globulin consists of more than 500 proteins, enzymes and antibodies.

The test is done to measure protein amounts as a routine check. It also helps identify potential risky health conditions such as kidney disease or liver disease. If the test comes back abnormal, further testing and analysis is required to determine which protein class is problematic, so that an accurate diagnosis can be made.

Determine the total amount of albumin in the blood sample.

Obtain the total amount of globulin in the blood sample.

Divide the globulin amount by the albumin amount to get the A/G ratio.

Analyse the results. In general, a bit more albumin is present than globulin. Hence, a normal A/G ratio is slightly over 1. A low ratio may be due to overproduction of globulin or underproduction of albumin, while a high ratio may be caused by underproduction of immunoglobulins.