What is WBC clumping?

Leukocyte agglutination can be observed in a laboratory.

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WBC stands for white blood cells, also called leukocytes. When white blood cells clump together, or agglutinate, the phenomenon is called leukocyte agglutination. Blood tests are used to detect WBC clumping.

Cells and Diseases

Laboratory blood tests can detect WBC clumping.

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Among the several different types of white blood cells, neutrophils typically are involved in leukocyte agglutination. Neutrophil agglutination can occur in response to an assortment of diseases or conditions.

Leukaemia

Some WBC clumping can signal the presence of serious diseases.

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A less common type of WBC clumping involves lymphocytes, a different type of white blood cell. Lymphocytic agglutination is associated with specific diseases, including non-Hodgkins lymphoma and chronic lymphocytic leukaemia.

  • WBC stands for white blood cells, also called leukocytes.
  • A less common type of WBC clumping involves lymphocytes, a different type of white blood cell.

Medical Treatments

Some medical treatments can cause WBC clumping.

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The man-made amino acid EDTA, used during chelation therapy to treat cholesterol build-up in blood vessels, can cause WBC clumping.

Cooling Blood Sample

Keeping a blood sample warm can help prevent misleading WBC clumping.

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WBC clumping also can be caused by a cooling temperature within a blood sample.

False Positives

Misleading results can lead to unnecessary tests.

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WBC clumping of any origin can cause blood tests to show a low white blood cell count. Avoiding the WBC clumping caused by temperature changes or other outside influences can help reduce misleading test results and unnecessary follow-up medical procedures or treatments.

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