Triple Flex Side Effects

Produced by Naturemade, Triple Flex is a type of dietary supplement advertised as improving joint comfort and reducing arthritis pain. Despite it is made of natural products, the ingredients in Triple Flex pose a risk for side effects in some people.


The main ingredients of Triple Flex are glucosamine hydrochloride, chondroitin sulphate and hyaluronatic acid, reports Naturemade. Other ingredients include white willow bark extract, cellulose gel, croscarmellose sodium, providone, polyvinyl alcohol, polythene glycol and artificial colours.

Types of Side Effects

Both glucosamine hydrochloride and white willow bark pose a risk for digestive side effects like gas, bloating and cramps, reports RxList. Side effects of chondroitin include diarrhoea, constipation, swollen eyelids, leg swelling and hair loss.

Drug Interactions

Glucosamine hydrochloride, white willow bark and chondroitin all pose a risk for sudden or prolonged bleeding following an injury or surgery when combined with blood-thinning medications, RxList reports. Because of this, it may not be safe to combine Triple Flex with warfarin, aspirin, clopidogrel, diclofenac, ibuprofen, naproxen, enoxaparin and heparin.


The glucosamine hydrochloride in Triple Flex comes from shellfish, which may cause severe allergic reactions in patients allergic to seafood. Chondroitin is also known to cause irregular heartbeat in some patients.


Because the effects of Triple Flex's ingredients upon fetal development are unknown, avoid taking the product while pregnant or nursing. If you have a history of asthma, an allergy to aspirin, stomach ulcers, diabetes, gout, haemophilia, kidney or liver disease or prostate cancer, it may not be safe for you to take Triple Flex, cautions RxList.