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Propalin Syrup Side Effects

Updated April 17, 2017

Propalin syrup is prescribed by veterinarians to treat canine urinary incontinence. The side effects of the drug are rare, but can include behavioural changes, lethargy, loss of appetite and diarrhoea. However, most of these side effects only arise in the event of an overdose.

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Propalin syrup is used to treat urinary incontinence----that is, an inability to hold urine in the bladder----in female dogs. This condition can usually be detected if a dog urinates while it is sleeping, or does so while lying down and awake. Urinary incontinence is a consequence of urethral sphincter incompetence, which requires lifelong medication or surgery. However, due to the fact that surgery to correct the problem often has a low success rate, veterinarians tend to prescribe phenylpropanolamine, otherwise known as Propalin syrup. This drug increases tone in the urethral sphincter muscles.

Change in Behavior

The most common side effect in dogs is aggressiveness and restlessness----the occurrence of which still remains quite rare. Behavioural changes that result from administering Propalin syrup should not warrant veterinary intervention.


Lethargy and a loss of appetite have been reported, but only in cases following an overdose. In the event of an overdose, it is a good idea to seek veterinary attention.


Propalin syrup contains sorbitol, which is known to have laxative properties. Thus, it is possible for a dog to experience diarrhoea after ingesting the drug; however, this side effect is unlikely if adhering to the recommended dose. Unless the diarrhoea is severe and lasts for an extended period of time, a veterinarian need not be contacted.


Propalin syrup should not be kept in a refrigerator, and should be stored away from direct sunlight. Furthermore, it should not be used in pregnant dogs, and the person administering the drug should not exceed the recommended dose.

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