What Are the Side Effects of the Depletion of Estrogen?

Updated February 21, 2017

Oestrogen depletion occurs when the body is not producing adequate amounts of the hormone, which happens for a variety of reasons. Many women experience a decline in oestrogen production during menopause, which occurs naturally between the ages of 45 and 55 on average, according to Christiane Northrup, M.D. Women can also experience menopause before the age of 40, which is called ovarian failure, and women who have their ovaries removed will experience a sudden drop in oestrogen levels.

Hot Flushes

Hot flushes are a common symptom of menopause and occur because of the depletion of oestrogen. The sensation of body heat can be debilitating for some women. Those who experience a sudden drop in oestrogen may experience stronger and more severe hot flushes, according to the University of Maryland Medical Center.

Vaginal Dryness

Vaginal dryness is an uncomfortable symptom of declining oestrogen levels. For women going through menopause, this also occurs when libido is diminished after menopause. These symptoms may go away after a time, according to the University of Maryland Medical Center.


Fatigue occurs in some women experiencing oestrogen depletion. A loss of ambition also occurs with fatigue in these women. Women who are experiencing sleeplessness because of hot flushes and night sweats are likely to feel fatigued. Fatigue may also be a symptom of depression.


Mood swings are common in menopausal women, but depression is likely to occur in the later stages, when oestrogen levels are at their lowest, according to Christiane Northrup, M.D. Depression is a serious mental condition that may be helped with hormone replacement therapy.


Women experiencing a drop in oestrogen may have headaches, mental fogginess and dizziness. Women who go through natural menopause will continue to make oestrogen, but in much lower amounts, according to Dr. Northrup.

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About the Author

Luanne Kelchner works out of Daytona Beach, Florida and has been freelance writing full time since 2008. Her ghostwriting work has covered a variety of topics but mainly focuses on health and home improvement articles. Kelchner has a degree from Southern New Hampshire University in English language and literature.