Side Effects of the Canine DA2PP Vaccine

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Side Effects of the Canine DA2PP Vaccine
Vaccinations prevent diseases, but at times may cause uncomfortable side effects. (dog image by Michal Tudek from

Vaccinations offer dogs great protection against many serious diseases, however, at times they may also cause unpleasant side effects. The DA2PP vaccine is a combination shot protecting against four diseases: distemper, adenovirus 2, parainfluenza and parvovirus. Should your dog develop any side effects following vaccination, report them to your veterinarian immediately.

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Anaphylactic Shock

Anaphylactic shock is a sudden, life-threatening allergic reaction triggered by the dog's immune system as a response to some portion of the vaccine. Symptoms of anaphlylactic shock are vomiting, diarrhoea, facial swelling, itching, trouble breathing, weakness, seizures, and even death, explains Dr. Lila Miller, a veterinarian for the ASPCA, in an article for Pet Finder. Should your dog develop any of these symptoms following the DA2PP vaccine, seek emergency veterinarian care immediately.

Side Effects of the Canine DA2PP Vaccine
Dogs may develop serious allergic reactions to components of shots. (vaccine image by Mykola Velychko from

Systemic Reactions

Some dogs may appear to be lethargic, less playful and may sleep more following the DA2PP shot . Loss of appetite may accompany these symptoms. Some dogs may also react with a slightly elevated temperature. Generally, these mild reactions tend to develop one to two days following vaccination, are short-lived and usually resolve without treatment, according to Pet Place veterinarians.

Side Effects of the Canine DA2PP Vaccine
Your dog may be sleepy and less active after his booster shot. (closeup of dog sleeping image by itay Uri from

Localised Reactions

Some dogs will develop local reactions, such as a lump, at the injection site. According to Vet Info, the lump generally absorbs into the dog's system within a day or two. Other local reactions include pain upon being touched, redness, irritation and, sometimes, the development of abscesses or other hard tissue formations. Local reactions usually resolve on their own but should be reported if they persist.

Side Effects of the Canine DA2PP Vaccine
Some dogs may not want to be touched following vaccination. (sleeping dog image by Samuel Birkan from

Other Side Effects

Some dogs have been known to develop nervous system problems after the administration of a modified live distemper vaccine. This condition is known as "vaccinial distemper" and takes place 10 to 21 days following the modified live vaccine, according to Mar Vista Animal Medical Center. In some cases, dogs have also developed autoimmune hemolytic anaemia, a condition where antibodies attack the body's own red blood cells, leaving the dog anaemic. This condition has been seen particularly following vaccination against parvo.

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