Phases of the Cardiac Action Potential

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Phases of the Cardiac Action Potential
The cardiac action potential has 5 phases. (stethoscope lying on a ekg image by Joseph Dudash from

The cardiac action potential differs from skeletal muscle action potentials in three ways: some cardiac muscle cells are self-excitable, all cardiac muscle cells are electrically connected by gap junctions and so contract together as a unit and the cardiac action potential has a much longer absolute refractory period--the period of time following a contraction during which the muscle cannot contract again. About 1% of cardiac fibres are auto-rhythmic, meaning they have the special ability to depolarise spontaneously and control the pace of the heart. These auto-rhythmic cells initiate the cardiac action potential. The cardiac action potential spans 5 phases, numbered 0-4.

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Phase 0

Phase 0 of the cardiac action potential is the rapid depolarisation phase. The auto-rhythmic cells of the heart have an unstable resting potential that continuously depolarises, constantly drifting toward threshold levels. These spontaneously changing membrane potentials--called pacemaker potentials--trigger the contractions of the heart. During the rapid depolarisation phase sodium ion channels on the membranes of the cells open up, and the influx of positive sodium ions helps to depolarise the cell further.

Phase 1

Phase 1 begins as the sodium ion channels begin to inactivate. Sodium influx slows, meanwhile the cell continues to lose potassium and chloride ions.

Phase 2

Phase 2 is the plateau phase of the cardiac action potential. When the threshold of approximately -40 mV is achieved, calcium ion channels open up. Calcium ions rush into the cell and begin the rising phase of the action potential, reversing the membrane potential.

Phase 3

Phase 3 is the rapid re-polarisation of the cardiac action potential. Potassium channels open, potassium ions flow from the cell and the cell re-polarises.

Phase 4

At phase 4 the cell has returned to resting membrane potential. However it will soon be stimulated to begin spontaneous depolarisation again.

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