The side effects of di-indole methane

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The side effects of di-indole methane
As men and women age, their oestrogen profiles can change. (woman image by Empath from

Di-indole methane (DIM) is a phytonutrient found in some vegetables that may have a role in controlling excess oestrogen levels. Oestrogen is implicated in perimenopause, premenstrual syndrome and enlarged prostate. DIM may aid in the controlling oestrogen by initiating similar biochemical pathways that metabolise oestrogen.


Excess oestrogen, known as oestrogen dominance, is implicated in diseases and conditions such as perimenopause. Perimenopause is indicated by a rise in oestrogen versus progesterone levels. DIM may help restore the balance of oestrogen to progesterone and control high levels of oestrogen prior to menstruation. No negative side effects for DIM have been reported, but it is not known if it is safe for pregnant or breastfeeding women to take DIM.

Enlarged Prostate

Men in their 50s and 60s experience a rise in oestrogen levels as well as a decrease in testosterone levels. Oestrogen tends to collect in the prostate and can contribute to an enlarged prostate. Men taking DIM for an enlarged prostate have not reported any significant side effects. DIM processed in the liver and it may not be safe for persons with liver conditions or disease to take DIM.

Oestrogen Imbalance

Ageing men and women can both suffer from an excess of oestrogen that is metabolised incorrectly in their bodies. Oestrogen that is metabolised into 16-hydroxy oestrogen is shown to be a factor in different types of cancer and obesity. DIM may help prevent the metabolism of oestrogen into the 16-hydroxy forms. DIM should not be taken in lieu of other medications for treating cancer and should not be considered as a cure to certain types of cancer associated with oestrogen imbalances.

Drug Interactions

If you are taking a life-saving medication for HIV or cardiovascular problems, any other life saving medication, birth control pills, or hormone replacement therapy medication, check with your health care provider for possible drug interactions before taking DIM.

Natural Sources of DIM

DIM is a natural component of cruciferous vegetables, which includes members of the cabbage family such as cabbage, cale, broccoli and cauliflower. However, therapeutic dosages are much higher, and use special ingredients to enhance the absorption of DIM. Very high intake of cruciferous vegetables may cause hypothyroidism by interfering with thyroid hormone synthesis.

The side effects of di-indole methane
Vegetables like cabbage are natural sources of DIM. (head of cabbage of the cabbage image by Romashchenko Anatoly from

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