Mice can be very destructive, damaging items by chewing them or leaving droppings on them. Mouse droppings (including urine) can transmit diseases. To protect items in your shed, and for sanitary reasons, you should eliminate mice and prevent them from making a home in a shed or other buildings on your property.
Remove brush, stacked wood and any other debris around the shed. These attract mice to the area. In addition, University of Georgia School of Forest Resources advises keeping trash containers tightly closed.
Tidy the shed, removing debris that could provide shelter or food for mice. This includes removing cardboard boxes and any other open containers.
Use a flashlight to inspect all walls, doors and windows of the shed for holes that mice may enter through. According to the University of Georgia School of Forest Resources, holes as small as your little finger may be large enough for a mouse to squeeze through.
Seal small holes with caulk. Seal holes larger than a quarter with wire mesh, followed by caulk, as suggested by University of Georgia School of Forest Resources.
Set out mouse traps inside the shed, with the shed door closed. You have a choice of different types of traps, including live traps. These capture the mice but do not kill them--if you use these, you will need to take the mouse, trap and all, away from your property to set it free or it will return. Other traps include spring traps and sticky traps. Bait the traps with peanut butter or cheese.
Check traps daily to dispose of mice, dead or alive. Wear a dust mask and rubber gloves to protect yourself from pathogens on the mice or in their droppings.
You can use poisonous bait to get rid of mice--however, this comes with more risks than using traps. The poison is dangerous for humans and pets, and not just the mice. Pets that eat the bait or eat a mouse that has consumed the bait may be sickened or killed.