Isuspm.exe is a process used by InstallShield Update Manager from Macrovision. Once it has been installed, it automatically checks for updates online and asks if you want to install them. Although it is not a malicious process, it can get annoying because it displays frequent pop-ups asking if you want to update. By removing it, you will not get the informed updates for InstallShield. If you do not use InstallShield products, removing it is very safe and won't interfere with any system processes.
Navigate to the InstallShield Update Manager instructions page (See Resources).
Click "Download the Update Manager uninstaller." and save it to your desktop. Double-click the saved uninstaller and click "Yes" to uninstall and remove InstallShield Update Manager. Move to the next step to remove any registry values.
Download and install CCleaner free (See Resources). Launch your program after it has installed and click the "Registry" button on the far left.
Click "Scan for issues" to locate any leftover Isuspm.exe registry values. When the scan is complete, click "Fix selected issues." Click "Yes" to back up and save your registry.
Click "Fix all Selected Issues" and click "OK" to remove the leftover values.
Click the Windows "Start" button and click "Search." Click "Search All Files and Folders" to open the search box. Click "More Advanced Options" and place a check on all the options.
Search for and delete the following file:
Click the Windows "Start" button and click "Run." Type "msconfig" (without quotes) and press "Enter" to open the Systems Configuration Utility.
Click the "Startup" tab and remove the check from "isuspm.exe." Click "OK" and restart your computer to complete the removal process.