Tylex Side Effects

Updated February 12, 2018

Tylex is a prescription pain reliever available in the United Kingdom. Containing paracetamol and codeine phosphate, the combination is commonly called co-codamol. Paracetamol is known as acetaminophen in the United States, and the combination of acetaminophen and codeine is available there as Tylenol with codeine. Many side effects are possible.

Common Side Effects

Common side effects associated with Tylex include confusion, constipation, difficulty urinating, dizziness, dry mouth, lightheadedness, mood changes, nausea, shortness of breath, slow heart rate and vomiting.

Drugs Worsening Drowsiness

The risk of drowsiness and sedation is significant, and is worsened by taking Tylex along with certain other drugs. These include alcohol, antihistamines, antipsychotic medications, barbiturates, benzodiazepines, sleep aids, tricyclic antidepressants and other opioid painkillers.

Tolerance and Dependency

If the patient takes this medication for lengthy time frames, Tylex can cause tolerance and be less effective at relieving pain. Patients also can become dependent when taking Tylex for a long time, which can result in withdrawal symptoms when discontinuing the medicine.

Liver and Kidney Issues

Infrequently, Tylex is associated with liver and kidney damage, particularly if the patient exceeds the prescribed dosage. Alcohol intake increases the risk of liver damage.

Rare Side Effects

Rarely, rashes, blood disorders and pancreas inflammation, or pancreatitis, have occurred after prolonged use of Tylex.

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About the Author

Shelley Moore is a journalist and award-winning short-story writer. She specializes in writing about personal development, health, careers and personal finance. Moore has been published in "Family Circle" magazine and the "Milwaukee Sentinel" newspaper, along with numerous other national and regional magazines, daily and weekly newspapers and corporate publications. She has a Bachelor of Science in psychology.