Allergic reactions to hernia mesh

Written by sumei fitzgerald
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Introduction
  • Introduction

    Allergic reactions to hernia mesh

    Surgical mesh has been used to help repair all different types of hernias since 1958, according to Dr. Timothy Kuwada, assistant clinical professor of surgery at University of North Carolina. Even though surgical mesh helps hernias to heal faster and with less pain than just closing a hernia, allergic reactions, complications and recurrence rates still abound. Dr. Yuri Novitsky, director of the Hernia Center at the University of Connecticut Health Center, explains that the ideal synthetic mesh has to be durable and strong and not contract within human tissue. It has to be hypoallergenic, noncarcinogenic and resistant to infection. It must be absorbed into body tissue without causing excessive inflammation or immune response and it has to be cost-effective.

    Most hernia mesh is based on mesh designed for the textile industry. (black mesh image by Paul Mitchell from Fotolia.com)

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    Surgical Mesh Complications

    Kuwada reports that infections and fistulas (abnormal holes) resulting from surgical mesh can be devastating. Research suggests that surgical mesh may increase chronic pain and discomfort as it inflames nerves and tissues and feels rigid and unnatural. The body recognises that the material isn’t organic and rejection and allergic reactions arise. The FDA also reports that the use of surgical mesh can result in adhesions of organs, injuries to nearby organs and damage to blood vessels and nerves.

    The body registers mesh as a foreign invader. (blood cells image by Marko Kovacevic from Fotolia.com)

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    Heavyweight Mesh Versus Lightweight Mesh

    Heavyweight mesh is made of heavier and sturdier material than the newer lightweight meshes. Because lightweight meshes contain less foreign material, it is thought that they may inspire less allergic and inflammatory reactions and less pain and contraction. Lightweight mesh, however, isn’t as strong as heavyweight mesh and hernia recurrence rates may be higher with its use. Novitsky says that even though evidence exists that lightweight mesh may give mild-to-moderate pain reduction in groin hernia repair, not enough evidence exists to state that it is better than heavyweight mesh.

    Mesh can sometimes cause organs to adhere to one another (blood image by Andrey Rakhmatullin from Fotolia.com)

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    Synthetic Surgical Mesh

    Dr. Bruce Ramshaw, chief of surgery at the University of Missouri, explains that in current practice, either woven mesh or nonwoven mesh is used. Woven mesh has large pores and comes in a variety of weaves. It is made of polypropylene, which has been compared to polyester. Nonwoven mesh is made of a Teflon derivative known as ePTFE. Because it is microporous, it minimises the ingrowth of tissue. These synthetic materials are the least expensive surgical meshes. Biomeshes currently are the most expensive choice, but Ramshaw reports that research of a new class of "nano" meshes embedded with growth factors and inflammation inhibitors is under way.

    Surgical mesh comes in different degrees of porosity (blue mesh image by Paul Hampton from Fotolia.com)

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    Biologic Mesh

    Biomeshes, surgical mesh made of human or other animal skin cells, were first developed in the 1990s for use in burn recovery. Since then, biomeshes have been developed for use in hernia and abdominal wall reconstruction. Dr. Scott Helton, chairman of surgery at the Hospital of St. Raphael in New Haven, reports that 13 biomeshes had been as of 2008. He also reports that six of those products have never undergone valid clinical study. Biomeshes are very expensive, but Helton believes the cost is balanced by the advantages: Biomesh is less likely to lead to fistulas, it speeds healing, it is more resistant to infection and may be more absorbable. Not enough is known about biomesh strength and hernia recurrence with their use. There is worry over viral infections carried in the animal tissue used and medical and legal issues concerning the implantation of animal tissue into humans.

    Many religious faiths object to the use of animal tissue in humans (Menora image by fra from Fotolia.com)

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    Surgical Mesh for Pelvic Organ Prolapse and Stress Urinary Incontinence

    The FDA has received over 1,000 reports from nine different surgical mesh manufacturers about complications when mesh is put in place through an incision in the wall of the vagina. Used to treat pelvic organ prolapse and stress urinary incontinence, this surgical mesh procedure has led to abcesses, infections, pain, urinary problems, erosion of the mesh into the vagina and vaginal scarring. Blood vessel, bladder and bowel injury have also occurred. The complications have not yet been linked to any one type or brand of surgical mesh.

    The use of mesh through incisions in the vaginal wall has resulted in serious complications. (surgery 2 image by rvvelde from Fotolia.com)

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    Recall of Kugel Mesh

    The most widely used hernia repair patches. Kugel mesh hernia patches were manufactured by Davol Inc. Patients who received Kugel mesh experienced reactions to the materials and breakdown of the product. The breakage has perforated patient bowels and obstructed bowels. Several patches have been recalled since 2005, reports the website "Drug Recall Side Effects News," including Bard and Composix.

    Kugel mesh was recalled for serious complications (medical equipment image by Chad McDermott from Fotolia.com)

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    Other Surgical Mesh Recalls

    The FDA has recalled a counterfeit surgical mesh illegally manufactured and distributed under the C.R. Bard/Davol brand name from Oct. 21, 2008, to Oct. 27, 2009. The product does not meet the Bard/Davol specifications for manufacture and they were not produced by that company. Surgical mesh with the brand name "Proceed" was the focus of a recall issued by the FDA in December 2005. This mesh delaminates and exposes the bowel to the polypropylene, increasing risk of organ adhesions and fistulas. Shelhigh Inc. has been making implantable medical devices, including surgical mesh, since 1997. The FDA ordered a seizure of all Shelhigh implantable devices in 2007 because they may have been manufactured under contaminated conditions.

    Thousands of people have surgical meshes that have since been recalled. (emergency help image by Andrey Kiselev from Fotolia.com)

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