Tibolone side effects

Updated March 23, 2017

Tibolone is a regimen of hormone replacement medicines that are meant for women undergoing menopause to help relieve the symptoms that are associated with "the change." Like any medicine, it carries risks with its benefits.

What is Tibolone?

Tibolone is a synthetic steroid that affect the way the ovaries produce oestrogen, testosterone and prostaglandins. It is used to treat women of menopausal age and alleviate symptoms such as hot flushes, night sweats, vaginal dryness and lowered libido.

While Tibolone is not an actual hormone, because of its action on reproductive hormones, it is classified with a group of drugs called HRTs-- or hormone replacement therapy drugs.

How does Tibolone work?

Tibolone helps to bring balance between the female sex hormones during menopause in women. When menopause strikes, women often experience a variety of symptoms due to the imbalance of hormones within the body. These symptoms are usually unpleasant and include hot flushes, sweating, mood swings, decreased sex drive and vaginal discomfort.

Because Tibolone works to restore hormonal balance, the symptoms of menopause are greatly decreased.

What are the common side effects associated with Tibolone?

The most common side effect of Tibolone is bleeding from the vagina. This is usually light and recedes after taking the medicine for several months.

Other common side effects include headaches, nausea, upset stomach, dizziness and rashes. These symptoms can usually be treated with over-the-counter remedies such as pain relievers or skin creams.

Eating light, frequent meals can help to reduce nausea.

What serious side effects does Tibolone use pose a risk?

If you should notice yellowing of the skin or eyes, swelling of the legs, sudden chest pain or shortness of breath, consult your physician or emergency help immediately.

These symptoms indicate liver failure and possible blood clot. Both situations can be life threatening if left untreated, so immediate medical intervention is necessary.


Patients who are pregnant, have a history of breast, uterine, ovarian or endometrial cancers, are diabetic, have gall bladder, kidney or liver disease, have blood clotting disorders or DVT, a history of strokes or heart attacks, or have epilepsy, should not use Tibolone.

Consult with your physician to determine the possible benefits and risks associated with the use of Tibolone in your own situation.

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About the Author

Leeann Teagno has been writing professionally since 2006. An English major, she continues to study information systems management at American Public University. Teagno is an organic gardener, cook and technology buff with past employment in mobile communications. She also volunteers at an animal shelter and operates a home bakery.